What is Dactinomycin?

Dactinomycin is a cancer (antineoplastic) medication. Dactinomycin interferes with the growth of cancer cells and slows their growth and spread in the body.
Dactinomycin is used to treat Wilm’s tumor, childhood rhabdomyosarcoma, Ewing’s sarcoma, and testicular cancer. Dactinomycin is also used in the treatment of gestational trophoblastic neoplasia and in the treatment of locally recurrent solid malignancies.
Dactinomycin may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking Dactinomycin?

Do not use dactinomycin without first talking to your doctor if you have:

• recently had chickenpox (varicella) or shingles (herpes zoster)
• any other type of infection; or
• decreased bone marrow function

The use of dactinomycin may be dangerous if you have any of the conditions listed above.
Dactinomycin is in the FDA pregnancy category D. This means that dactinomycin is known to be harmful to an unborn baby. Do not use dactinomycin without first talking to your doctor if you are pregnant. Discuss with your doctor the appropriate use of birth control during treatment with dactinomycin if necessary.
It is not know whether dactinomycin passes into breast milk. Breast feeding should be avoided during treatment with dactinomycin.

Dactinomycin Side Effects

What are the possible side effects of Dactinomycin?

If you experience any of the following serious side effects from dactinomycin, seek emergency medical attention or contact your doctor immediately:

• an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
• decreased bone marrow function and blood problems (extreme fatigue; increased susceptibility to infection; slow wound healing; easy bruising or bleeding; or sore throat, fever, chills, or signs of infection)
• abdominal pain or black, bloody, or tarry stools
• sore mouth (inflamation and sores on the lips or inside the mouth)
• severe nausea, vomiting, diarrhea, or loss of appetite; or
• redness, pain, or swelling at the place of injection or anywhere else on your skin

In some cases, second malignancies have been reported to occur during and following treatment with dactinomycin. Talk to your doctor about the risks and benefits of this medication.
Other, less serious side effects may be more likely to occur. Continue taking dactinomycin and talk to your doctor if you experience:

• hair loss
• fatigue
• mild to moderate nausea, vomiting, or loss of appetite; or
• skin eruptions, acne, or a flare-up of skin redness or increased color of the skin where radiation treatments were done

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

Dactinomycin Interactions

What other drugs affect Dactinomycin?

Other medications may interact with dactinomycin. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with dactinomycin.

What should I avoid while taking Dactinomycin?

Dactinomycin can lower the activity of your immune system making you susceptible to infections. Avoid contact with people who have colds, the flu, or other contagious illnesses and do not receive vaccines that contain live strains of a virus (e.g., live oral polio vaccine) during treatment with dactinomycin. In addition, avoid contact with individuals who have recently been vaccinated with a live vaccine. There is a chance that the virus can be passed on to you.
Dactinomycin is extremely corrosive to the skin if contact occurs. If you are storing or injection dactinomycin at home, avoid contact with the medication. If contact accidentally occurs, rinse the skin with water for at least 15 minutes and seek emergency medical attention.

Dactinomycin Dosage

How should I take Dactinomycin?

Dactinomycin should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.
Tell your doctor or nurse right away if you notice redness, pain, or swelling at the place of injection or anywhere else on your skin.
Your doctor will determine the correct amount and frequency of treatment with dactinomycin depending upon the type of cancer being treated and other factors. Talk to your doctor if you have any questions or concerns regarding the treatment schedule.
Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with dactinomycin to monitor progress and side effects.
Dactinomycin is extremely corrosive to the skin if contact occurs. If you are storing or injection dactinomycin at home, avoid contact with the medication. If contact accidentally occurs, rinse the skin with water for at least 15 minutes and seek emergency medical attention.
Your healthcare provider will store dactinomycin as directed by the manufacturer. If you are storing dactinomycin at home, follow the directions provided by your healthcare provider.

What happens if I overdose on Dactinomycin?

If, for any reason, an overdose of dactinomycin is suspected, seek emergency medical attention or contact your healthcare provider immediately.
Symptoms of a dactinomycin overdose tend to be similar to side effects caused by the medication, although often more severe.

What happens if I miss a dose of Dactinomycin?

Contact your doctor if you miss a dose of dactinomycin.
Sourced from everydayhealth.com