What is Dalfampridine?

Dalfampridine is a potassium channel blocker.
Dalfampridine is used to improve walking in patients with multiple sclerosis (MS).
Dalfampridine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Dalfampridine?

You should not use dalfampridine if you are allergic to it, or if you have moderate to severe kidney disease, if you have ever had a seizure (convulsions), or if you are also taking another multiple sclerosis drug called Fampridine.
If you have mild kidney disease, you may need a dose adjustment or special tests.
Do not take more than 2 tablets in a 24-hour period. Do not use a tablet that has been broken or crushed. A broken tablet can release too much of the drug at one time. This can increase your risk of having a seizure.
Stop taking dalfampridine and call your doctor at once if you a seizure, pain or burning when you urinate, problems with your balance, numbness or tingly feeling, or a relapse of your MS symptoms.

What should I discuss with my healthcare provider before taking Dalfampridine?

You should not use dalfampridine if you are allergic to it, or if you have:

moderate to severe kidney disease
if you have ever had a seizure (convulsions); or
if you are also taking another MS drug called Fampridine (4-aminopyridine)

If you have mild kidney disease, you may need a dalfampridine dose adjustment or special tests.
FDA pregnancy category C. It is not known whether dalfampridine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication..
It is not known whether dalfampridine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking dalfampridine.
Do not give this medication to anyone under 18 years old without the advice of a doctor.

Dalfampridine Side Effects

What are the possible side effects of Dalfampridine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop taking dalfampridine and call your doctor at once if you have a serious side effect such as:

seizure (convulsions)
pain or burning when you urinate
problems with balance
numbness, burning pain, or tingly feeling
relapse or worsening of MS symptoms

Less serious side effects may include:

headache, dizziness
sleep problems (insomnia)
nausea, constipation, upset stomach
weakness
back pain
stuffy nose, sinus pain, sore throat; or
mild skin itching

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Dalfampridine Interactions

What other drugs affect Dalfampridine?

There may be other drugs that can interact with dalfampridine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

What should I avoid while taking Dalfampridine?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity.

Dalfampridine Dosage

How should I take Dalfampridine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Dalfampridine is usually taken once every 12 hours. Follow your doctor’s instructions.
Do not take more than 2 tablets in a 24-hour period.
Dalfampridine may be taken with or without food.
Do not crush, chew, or break an extended-release tablet. Swallow it whole. Do not dissolve the tablet in liquid. Breaking or dissolving the pill may cause too much of the drug to be released at one time.
Do not use a dalfampridine tablet that has been accidentally crushed or broken. This can increase your risk of having a seizure.
Store at room temperature away from moisture and heat.
Throw away any leftover medicine after the expiration date on the label has passed.

What happens if I overdose on Dalfampridine?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose can cause confusion, problems with thinking or memory, tremors, sweating, or seizures.

What happens if I miss a dose of Dalfampridine?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Sourced from everydayhealth.com

Dalfampridine