What is Milrinone?
Milrinone is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries.
Milrinone is used as a short-term treatment for treat life-threatening heart failure.
Milrinone may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about Milrinone?
You should not receive this medication if you are allergic to milrinone, or if you have recently had a heart attack.
If possible before you receive milrinone, tell your doctor if you have a heart rhythm disorder or low levels of potassium in your blood (hypokalemia), or if you are pregnant or breast-feeding.
In an emergency situation, it may not be possible before you are treated to tell your caregivers about any health conditions you have or if you are pregnant or breast-feeding. However, make sure any doctor caring for you afterward knows that you have received this medication.
Tell your doctor about all other medications you use, especially digoxin (digitalis, Lanoxin, Lanoxicaps), or a diuretic (water pill).
While receiving milrinone, tell your caregivers at once if you have a serious side effect such as chest pain, feeling like you might pass out, wheezing or trouble breathing, confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, or muscle weakness.
What should I discuss with my healthcare provider before taking Milrinone?
You should not receive this medication if you are allergic to milrinone, or if you have recently had a heart attack.
If possible before you receive milrinone, tell your doctor if you have a heart rhythm disorder or low levels of potassium in your blood (hypokalemia).
FDA pregnancy category C. It is not known whether milrinone is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether milrinone passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
In an emergency situation, it may not be possible before you are treated with milrinone to tell your caregivers if you are pregnant or breast-feeding. However, make sure any doctor caring for your pregnancy or your baby knows that you have received this medication.
Milrinone Side Effects
What are the possible side effects of Milrinone?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have a serious side effect such as:
- chest pain
- feeling like you might pass out
- bronchospasm (wheezing, chest tightness, trouble breathing); or
- low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling)
Less serious side effects may include:
- headache
- tremors; or
- easy bruising or bleeding
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Milrinone Interactions
What other drugs affect Milrinone?
Tell your doctor about all other medications you use, especially:
- digoxin (digitalis, Lanoxin, Lanoxicaps); or
- diuretic (water pill)
This list is not complete and there may be other drugs that can interact with milrinone. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
What should I avoid while taking Milrinone?
Follow your doctor’s instructions about any restrictions on food, beverages, or activity after your treatment with milrinone.
Milrinone Dosage
How should I take Milrinone?
Milrinone is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. Milrinone is usually given around-the-clock for up to 48 hours.
Your heart rate and blood pressure will be constantly monitored while you are being treated with milrinone. Your kidney function and electrolytes may also need to be checked with blood tests.
What happens if I overdose on Milrinone?
Tell your caregivers right away if you think you have received too much of this medicine.
Overdose can cause severe dizziness or fainting.
What happens if I miss a dose of Milrinone?
Since milrinone is given by a healthcare professional, you are not likely to miss a dose.
Edited from everydayhealth.com