What is Menostar (Estradiol)?

Estradiol is a form of estrogen, a female sex hormone the regulates many processes in the body.
Estradiol transdermal skin patches are used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area. Estradiol transdermal also reduces urgency or irritation of urination.
Estradiol skin patches are also used to treat ovarian disorders, infertility, and abnormal vaginal bleeding. Some estradiol skin patches are used to prevent postmenopausal osteoporosis. Transdermal skin patches release the drug slowly, and it is absorbed through your skin.
Estradiol transdermal may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Menostar (Estradiol)?

Do not use this medication if you have any of the following conditions: a history of stroke or blood clot, circulation problems, a bleeding disorder, a hormone-related cancer such as breast or uterine cancer, or abnormal vaginal bleeding.
This medication can cause birth defects in an unborn baby. Do not use if you are pregnant. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.
Estradiol increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol transdermal.
Long-term estradiol treatment may increase your risk of breast cancer, heart attack, or stroke. Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.
Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using estradiol transdermal.

What should I discuss with my healthcare provider before taking Menostar (Estradiol)?

Do not use estradiol transdermal if you have:

a bleeding or blood-clotting disorder
a history of stroke or circulation problems
abnormal vaginal bleeding that a doctor has not checked; or
any type of breast, uterine, or hormone-dependent cancer

Before using estradiol transdermal, tell your doctor if you have:

high blood pressure, angina, or heart disease
high cholesterol or triglycerides
liver disease
kidney disease
asthma
epilepsy or other seizure disorder
migraines
diabetes
depression
gallbladder disease; or
if you have had your uterus removed (hysterectomy)

If you have any of these conditions, you may need a dose adjustment or special tests to safely use estradiol transdermal.
Estradiol increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol transdermal.
Long-term estradiol treatment may increase your risk of stroke. Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.
FDA pregnancy category X. This medication can cause birth defects. Do not use estradiol transdermal if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use an effective form of birth control while you are using this medication.
Estradiol can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast-feeding a baby.

Menostar Side Effects

What are the possible side effects of Menostar (Estradiol)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling
sudden numbness or weakness, especially on one side of the body
sudden headache, confusion, problems with vision, speech, or balance
pain or swelling in your lower leg
abnormal vaginal bleeding
pain, swelling, or tenderness in your stomach
jaundice (yellowing of the skin or eyes); or
a lump in your breast

Less serious side effects may include:

nausea, vomiting, loss of appetite
swollen breasts
acne or skin color changes
decreased sex drive, impotence, or difficulty having an orgasm
migraine headaches or dizziness
vaginal pain, dryness, or discomfort
swelling of your ankles or feet
depression; or
changes in your menstrual periods, break-through bleeding

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Menostar Interactions

What other drugs affect Menostar (Estradiol)?

Before using estradiol transdermal, tell your doctor if you are using any of the following drugs:

St. John’s wort
phenobarbital (Luminal, Solfoton)
a blood thinner such as warfarin (Coumadin)
ritonavir (Norvir)
carbamazepine (Carbatrol, Tegretol)
an antibiotic such as clarithromycin (Biaxin), erythromycin (E-Mycin, E.E.S., Erythrocin, Ery-Tab), or rifampin (Rifadin, Rifater, Rifamate, Rimactane); or
an antifungal medication such as ketoconazole (Nizoral) or itraconazole (Sporanox)

This list is not complete and there may be other drugs that can interact with estradiol transdermal. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

What should I avoid while taking Menostar (Estradiol)?

Avoid using other estrogen products without your doctor’s advice.

Menostar Dosage

How should I take Menostar (Estradiol)?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.
Apply the skin patch to clean, dry skin on your stomach, lower back, or buttocks. Choose a different spot within these skin areas each time you apply a new patch. Avoid skin that is oily, irritated, or damaged.
Press the patch in place firmly for about 10 seconds, especially around the edges.
Do not apply a skin patch to your breasts. Do not apply a patch where it might be rubbed off by tight clothing, such as under an elastic waistband.
If a patch falls off, try putting it back on to a different skin area, pressing the patch into place for 10 seconds. If the patch will not stick you may apply a new one.
Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using estradiol transdermal.
Store this medication at room temperature away from moisture and heat.

What happens if I overdose on Menostar (Estradiol)?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, and vaginal bleeding.

What happens if I miss a dose of Menostar (Estradiol)?

Apply a skin patch as soon as you remember. If it is almost time to apply your next patch, skip the missed dose and apply a patch at the next regularly scheduled time. Do not use extra patches to make up the missed dose.
Edited from everydayhealth.com

Menostar (Estradiol)