What is Meclofenamate?

Meclofenamate is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Meclofenamate works by reducing hormones that cause inflammation and pain in the body.
Meclofenamate is used to treat pain or inflammation caused by arthritis. It is also used to treat menstrual pain.
Meclofenamate may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Meclofenamate?

This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).
Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.
This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking meclofenamate. Older adults may have an even greater risk of these serious gastrointestinal side effects.
Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

What should I discuss with my healthcare provider before taking Meclofenamate?

Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).
NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.
Do not use this medication if you are allergic to meclofenamate, or to aspirin or other NSAIDs.
Before taking meclofenamate, tell your doctor if you are allergic to any drugs, or if you have:

• a history of heart attack, stroke, or blood clot
• heart disease, congestive heart failure, high blood pressure
• a history of stomach ulcers or bleeding, bowel problems, diverticulosis
• liver or kidney disease
• asthma
• polyps in your nose; or
• if you smoke

If you have any of these conditions, you may need a dose adjustment or special tests to safely take meclofenamate.
FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking meclofenamate during the last 3 months of pregnancy may harm the unborn baby. Do not take meclofenamate during pregnancy unless your doctor has told you to.
Meclofenamate passes into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Do not give this medicine to a child younger than 14 years old without the advice of a doctor.

Meclofenamate Side Effects

What are the possible side effects of Meclofenamate?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking meclofenamate and call your doctor at once if you have any of these serious side effects:

• chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance
• black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds
• urinating less than usual or not at all
• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
• bruising, severe tingling, numbness, pain, muscle weakness

Less serious side effects may include:

• upset stomach, mild heartburn or stomach pain, diarrhea, constipation; bloating, gas
• dizziness, headache, nervousness
• skin itching or rash
• dry mouth
• increased sweating, runny nose
• blurred vision; or
• ringing in your ears

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Meclofenamate Interactions

What other drugs affect Meclofenamate?

Before taking meclofenamate, tell your doctor if you are taking any of the following drugs:

• cyclosporine (Gengraf, Neoral, Sandimmune)
• a diuretic (water pill) such as furosemide (Lasix)
• lithium (Eskalith, Lithobid)
• a blood thinner such as warfarin (Coumadin)
• steroids (prednisone and others); or
• heart or blood pressure medication such as candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), losartan (Cozaar, Hyzaar), olmesartan (Benicar), telmisartan (Micardis), or valsartan (Diovan)
• a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), esmolol (Brevibloc), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others
• an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik); or
• aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others

This list is not complete and there may be other drugs that can interact with meclofenamate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

What should I avoid while taking Meclofenamate?

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain medicines similar to meclofenamate (such as aspirin, ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.
Do not drink alcohol while taking meclofenamate. Alcohol can increase the risk of stomach bleeding.
If you take cholestyramine (Prevalite, Questran), avoid taking it within 2 hours before or after you take meclofenamate.

Meclofenamate Dosage

How should I take Meclofenamate?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. The maximum amount of meclofenamate for adults is 400 milligrams (mg) per day. Know the amount of meclofenamate in the specific product you are taking.
If you take meclofenamate for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.
Store meclofenamate at room temperature, away from moisture, heat, and light.

What happens if I overdose on Meclofenamate?

Seek emergency medical attention if you think you have used too much of this medicine.
Overdose symptoms may include nausea, vomiting, dizziness, drowsiness, ringing in your ears, numbness or tingling, black or bloody stools, coughing up blood, fever, urinating less than usual or not at all, shallow breathing, fainting, and seizure (convulsion

What happens if I miss a dose of Meclofenamate?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Edited from everydayhealth.com