What is Estradiol Norgestimate?

Estradiol is a female sex hormone that is involved in the development and maintenance of the female reproductive system.
Norgestimate is a form of progesterone. Progesterone is a female hormone important for the regulation of ovulation and menstruation.
Estradiol and norgestimate is used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. It is also used to prevent osteoporosis.
Estradiol and norgestimate may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Estradiol Norgestimate?

Do not use this medication if you have any of the following conditions: a history of stroke or blood clot, circulation problems, a hormone-related cancer such as breast or uterine cancer, or abnormal vaginal bleeding.
This medication can cause birth defects in an unborn baby. Do not use if you are pregnant. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.
Estradiol and norgestimate increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol and norgestimate may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol and norgestimate.
Long-term estradiol and norgestimate treatment may increase your risk of breast cancer, heart attack, or stroke. Talk with your doctor about your individual risks before using estradiol and norgestimate long-term. Your doctor should check your progress on a regular basis to determine whether you should continue this treatment.

What should I discuss with my healthcare provider before taking Estradiol Norgestimate?

Do not take estradiol and norgestimate without first talking to your doctor if you have

a bleeding or blood-clotting disorder
a history of stroke or circulation problems
abnormal vaginal bleeding that a doctor has not checked; or
any type of breast, uterine, or hormone-dependent cancer

Before using estradiol and norgestimate, tell your doctor if you have:

high blood pressure, angina, or heart disease
high cholesterol or triglycerides
liver disease
kidney disease
asthma
epilepsy or other seizure disorder
migraines
diabetes
depression
gallbladder disease
uterine fibroids; or
if you have had your uterus removed (hysterectomy)

Estradiol and norgestimate increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol and norgestimate may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol and norgestimate.
Long-term estradiol and norgestimate treatment may increase your risk of stroke. Talk with your doctor about your individual risks before using estradiol and norgestimate long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.
FDA pregnancy category X. This medication can cause birth defects. Do not use estradiol and norgestimate if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use an effective form of birth control while you are using this medication.
Estradiol and norgestimate can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast-feeding a baby.

Estradiol Norgestimate Side Effects

What are the possible side effects of Estradiol Norgestimate?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling
sudden numbness or weakness, especially on one side of the body
sudden headache, confusion, problems with vision, speech, or balance
pain or swelling in your lower leg
abnormal vaginal bleeding
pain, swelling, or tenderness in your stomach
jaundice (yellowing of the skin or eyes); or
a lump in your breast

Less serious side effects may include:

nausea, vomiting, loss of appetite
swollen breasts
swelling of your hands or feet
problems with wearing contact lenses
acne or skin color changes
migraine headaches or dizziness
vaginal pain, dryness, itching, or discharge
swelling of your ankles or feet
depression
enlargement of uterine fibroids; or
changes in your menstrual periods, break-through bleeding

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Estradiol Norgestimate Interactions

What other drugs affect Estradiol Norgestimate?

Before taking estradiol and norgestimate, tell your doctor if you are taking any of the following medicines

insulin or an diabetes medicine you take by mouth, such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), chlorpropamide (Diabinese), tolazamide (Tolinase), tolbutamide (Orinase), and others; or
a blood thinner such as warfarin (Coumadin)

If you are using any of these drugs, you may not be able to use estradiol and norgestimate or you may need dosage adjustments or special tests during treatment.
There may be other drugs not listed that can affect estradiol and norgestimate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

What should I avoid while taking Estradiol Norgestimate?

There are no restrictions on food, beverages, or activity while using estradiol and norgestimate unless your doctor has told you otherwise.

Estradiol Norgestimate Dosage

How should I take Estradiol Norgestimate?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label.
Take this medication with a full glass of water.
This medication usually comes in a pack of pills that are different colors. In most cases, you will take a pill of one color for three days in a row, followed by taking a pill of the other color for the next three days. This cycle is then repeated throughout your treatment.
Each time you start a new pack, start with the first tablet in the first row of pills. Your medication may come with stickers to mark your weekday schedule on the pack.
Be sure to have a new pack of this medication ready to start on the day after you have finished an entire pill pack.
Try to take estradiol and norgestimate at the same time each day.
Have yearly physical exams and examine your breasts for lumps on a monthly basis while taking estradiol and norgestimate.
Store estradiol and norgestimate at room temperature away from moisture and heat.

What happens if I overdose on Estradiol Norgestimate?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an estradiol and norgestimate overdose may include nausea, vomiting, or vaginal bleeding.

What happens if I miss a dose of Estradiol Norgestimate?

Take the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
If you miss 2 doses in a row, take the next tablet in order and keep taking only one pill per day. Call your doctor if you miss more than 2 doses of this medication.
Sourced from everydayhealth.com

Estradiol Norgestimate