Empty sella syndrome is a condition in which the pituitary gland shrinks or becomes flattened.
Overview, Causes, & Risk Factors
The pituitary gland is a small gland located at the base of the brain. It sits in a saddle-like compartment in the skull called the “sella turcica,” which in Latin means “Turkish saddle.”
When the pituitary gland shrinks or becomes flattened, it cannot be seen on MRI scans, giving the appearance of an “empty sella.” This is referred to as empty sella syndrome.
The pituitary makes several hormones that control the other glands in the body, including the:
- Adrenal glands
Primary empty sella syndrome occurs when a hole in the membrane covering the pituitary gland allows fluid in, which presses on the pituitary.
Secondary empty sella syndrome occurs when the sella is empty because the pituitary gland has been damaged by:
- A tumor
- Radiation therapy
Empty sella syndrome may be seen in a condition called pseudotumor cerebri. This is a condition seen most commonly in obese women.
Pictures & Images
The pituitary is a gland attached to the base of the brain which secretes hormones that govern the onset of puberty, sexual development and reproductive function.
Review Date : 11/23/2009
Reviewed By : Ari S. Eckman, MD, Division of Endocrinology and Metabolism, Johns Hopkins School of Medicine, Baltimore, MD. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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