Definition
Dubin-Johnson syndrome is a disorder passed down through families (inherited) in which a person has mild jaundice throughout life.
Overview, Causes, & Risk Factors
Dubin-Johnson syndrome is a very rare genetic disorder. In order to inherit the condition, a child must get a copy of the defective gene from both parents.
The syndrome interferes with the body’s ability to move bilirubin from the liver. Bilirubin is produced when the liver breaks down worn-out red blood cells. It normally moves through the bile produced by the liver and into the bile ducts, past the gallbladder, and into the digestive system.
When bilirubin is not properly processed, it builds up in the bloodstream and causes the skin and the whites of the eyes to turn yellow (jaundiced). Severely high levels of bilirubin can damage the brain and other organs.
People with Dubin-Johnson syndrome have life-long mild jaundice that may be made worse by:
- Alcohol
- Birth control pills
- Infection
- Other environmental factors that affect the liver
- Pregnancy
Pictures & Images
Digestive system organs
The digestive system organs in the abdominal cavity include the liver, gallbladder, stomach, small intestine and large intestine.
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Dubin-Johnson syndrome : Overview, Causes, & Risk Factors
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Dubin-Johnson syndrome : Symptoms & Signs, Diagnosis & Tests
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Dubin-Johnson syndrome : Treatment
Review Date : 7/22/2008
Reviewed By : David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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