What is Probenecid?
Probenecid helps your body pass uric acid out through the urine, which lowers the levels of uric acid in the body.
Probenecid is used to treat gout and gouty arthritis. Probenecid is also sometimes given together with penicillin antibiotics to make them more effective.
Probenecid may also be used for other purposes not listed in this medication guide.
What is the most important information I should know about Probenecid?
You should not use this medication if you are allergic to probenecid, or if you have uric acid kidney stones, a gout attack that has already started, or a blood cell disorder such as anemia, or decreased white blood cells. Probenecid should not be given to a child younger than 2 years old.
Before taking probenecid, tell your doctor if you are allergic to any drugs, or if you have kidney disease, a history of stomach ulcer, or if you have ever had kidney stones.
Drink plenty of water to prevent kidney stones while you are taking probenecid.
Probenecid may be only part of a complete program of treatment that also includes diet, other medications, and mineral supplements. Follow your doctor’s instructions.
Call your doctor at once if you have worsening gout symptoms, severe pain in your side or lower back, blood in your urine, swelling, fever, pale or yellowed skin, or dark-colored urine.
What should I discuss with my healthcare provider before taking Probenecid?
You should not use this medication if you are allergic to probenecid, or if you have:
- uric acid kidney stones
- a gout attack that has already started; or
- a blood cell disorder such as anemia, or decreased white blood cells
Before taking probenecid, tell your doctor if you are allergic to any drugs, or if you have:
- kidney disease
- a history of stomach ulcer; or
- if you have ever had kidney stones
If you have any of these conditions, you may need a dose adjustment or special tests to safely take probenecid.
Probenecid may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether probenecid passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Probenecid should not be given to a child younger than 2 years old.
Probenecid Side Effects
What are the possible side effects of Probenecid?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
* worsening gout symptoms
* severe pain in your side or lower back
* blood in your urine
* swelling, especially in your face, stomach, ankles, or feet; or
* pale or yellowed skin, dark colored urine, fever, confusion or weakness
Less serious side effects may include:
* urinating more than usual
* mild nausea, vomiting, loss of appetite
* headache, dizziness
* sore gums
* mild itching or skin rash
* hair loss; or
* warmth, redness, or tingly feeling under your skin
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Probenecid Interactions
What other drugs affect Probenecid?
Many drugs can interact with probenecid. Below is just a partial list. Tell your doctor if you are using:
- lorazepam (Ativan)
- methotrexate (Rheumatrex, Trexall)
- rifampin (Rifadin, Rifamate, Rimactane)
- diabetes medication you take by mouth
- an NSAID (nonsteroidal anti-inflammatory drug) such as ketoprofen (Orudis, Oruvail), indomethacin (Indocin), meclofenamate (Meclomen), or naproxen (Aleve, Anaprox, Naprosyn)
- salicylates such as aspirin, Novasal, Doan’s Extra Strength, Salflex, Tricosal, and others; or
- a sulfa drug such as Bactrim, Cotrim, Septra, SMX/TMP, and others
This list is not complete and there may be other drugs that can interact with probenecid. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
What should I avoid while taking Probenecid?
Follow your doctor’s instructions about any restrictions on food, beverages, or activity while you are using probenecid.
Probenecid Dosage
How should I take Probenecid?
Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.
Drink plenty of water to prevent kidney stones while you are taking probenecid.
Probenecid may be only part of a complete program of treatment that also includes diet, other medications, and mineral supplements. Follow your doctor’s instructions.
To be sure this medication is not causing harmful effects, your blood or urine may need to be tested on a regular basis. Do not miss any scheduled appointments.
If you are taking probenecid together with an antibiotic, be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.
If you need to have any type of surgery, tell the surgeon ahead of time that you are taking probenecid. This medication may affect your body’s response to anesthesia.
Store probenecid at room temperature away from moisture and heat.
What happens if I overdose on Probenecid?
Seek emergency medical attention if you think you have used too much of this medicine.
Overdose symptoms may include nausea, vomiting, or stomach upset.
What happens if I miss a dose of Probenecid?
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
Sourced from everydayhealth.com