What is Naproxen-sumatriptan?

Sumatriptan is a headache medicine. It is believed to work by narrowing the blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.
Naproxen is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen works by reducing hormones that cause inflammation and pain in the body.
The combination of sumatriptan and naproxen is used to treat migraine headaches.
Sumatriptan and naproxen will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks. This medication should not be used to treat a migraine that causes visual aura (such as flickering lights) with weakness on one side of the body, speech problems, ringing in your ears.
Sumatriptan and naproxen may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Naproxen-sumatriptan?

Do not take more than 2 sumatriptan and naproxen tablets in 24 hours.
You should not use this medication if you are allergic to sumatriptan (Imitrex) or naproxen (Aleve, Anaprox, Naprosyn), or if you have a history of asthma or allergic reaction caused by aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs).
Do not take sumatriptan and naproxen if you have liver disease, uncontrolled high blood pressure, or a history of heart disease, angina (chest pain), blood circulation problems, heart attack, stroke, or heart bypass surgery.
Do not take sumatriptan and naproxen if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), selegiline (Eldepryl, Emsam), or phenelzine (Nardil) in the past 14 days.
Do not take sumatriptan and naproxen within 24 hours before or after taking any of the following medications: almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt, Maxalt-MLT), sumatriptan (Imitrex), or zolmitriptan (Zomig), or ergot medicine such as methysergide (Sansert), ergotamine (Ergomar, Ergostat, Cafergot, Ercaf, Wigraine), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), methylergonovine (Methergine).

What should I discuss with my healthcare provider before taking Naproxen-sumatriptan?

You should not use this medication if you are allergic to sumatriptan (Imitrex), naproxen (Aleve, Anaprox, Naprosyn), or if you have a history of asthma or allergic reaction caused by aspirin or other NSAIDs such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others.
Do not take sumatriptan and naproxen if you have:

liver disease
untreated or uncontrolled high blood pressure; or
a history of heart disease, angina (chest pain), blood circulation problems, heart attack, stroke, or heart bypass surgery (also called coronary artery bypass graft, or CABG)

Do not take sumatriptan and naproxen if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or phenelzine (Nardil) in the past 14 days.
Do not take sumatriptan and naproxen within 24 hours before or after taking any of the following medicines:

almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt, Maxalt-MLT), sumatriptan (Imitrex), or zolmitriptan (Zomig); or
ergot medicine such as methysergide (Sansert), ergotamine (Ergomar, Ergostat, Cafergot, Ercaf, Wigraine), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), methylergonovine (Methergine)

If you any of these other conditions, you may need a dose adjustment or special tests to safely use sumatriptan and naproxen:

high blood pressure
congestive heart failure
epilepsy or other seizure disorder
liver disease
kidney disease; or
coronary artery disease (or risk factors that include diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy)

FDA pregnancy category C. Sumatriptan and naproxen may be harmful to an unborn baby. Tell your doctor if you are pregnant before you take this medication. Taking naproxen during the last 3 months of pregnancy may result in birth defects. Do not take sumatriptan and naproxen during pregnancy without your doctor’s advice.
Sumatriptan and naproxen can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Naproxen-sumatriptan Side Effects

What are the possible side effects of Naproxen-sumatriptan?

Get emergency medical help if you have any of these signs of an allergic reaction: runny or stuffy nose; hives; wheezing or trouble breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you a serious side effect such as:

chest pain or pressure, tight feeling in your neck or jaw, pain spreading to your arm or shoulder
sudden numbness or weakness, confusion, problems with vision, speech, or balance
bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
urinating less than usual or not at all
pale skin, weakness, easy bruising, flu symptoms
swelling or rapid weight gain
numbness, tingling, pale or blue-colored appearance in your fingers or toes
severe blistering, peeling, and red skin rash
seizure (convulsions); or
anxiety, restlessness, high fever, sweating, memory problems, trouble concentrating, loss of coordination, vomiting, diarrhea, fast heart rate, hallucinations, or fainting

Less serious side effects may include:

dizziness, drowsiness
constipation, dizziness, indigestion, dry mouth
warmth, numbness, or tingly feeling
redness in your face
tight muscles; or
mild pressure or heavy feeling in any part of your body

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Naproxen-sumatriptan Interactions

What other drugs affect Naproxen-sumatriptan?

Many drugs can interact with sumatriptan and naproxen. Below is just a partial list. Tell your doctor if you are using:

a blood thinner such as warfarin (Coumadin)
lithium (Eskalith, Lithobid)
methotrexate (Rheumatrex, Trexall)
probenecid (Benemid)
a diuretic (water pill) such as furosemide (Lasix)
steroids (prednisone and others)
aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), meloxicam (Mobic), and others
an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others
a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), and others; or
an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor)

This list is not complete and there may be other drugs that can interact with sumatriptan and naproxen. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

What should I avoid while taking Naproxen-sumatriptan?

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Medicines available over the counter contain aspirin, naproxen, or other medicines similar to naproxen (such as ibuprofen or ketoprofen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.
Do not drink alcohol while taking sumatriptan and naproxen. Alcohol can increase the risk of stomach bleeding caused by naproxen.
Sumatriptan and naproxen can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Naproxen-sumatriptan Dosage

How should I take Naproxen-sumatriptan?

Use this medication exactly as it was prescribed for you. Follow the instructions on your prescription label.
Never use more than the recommended dose of sumatriptan and naproxen. Overuse of migraine headache medicine can actually make your headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks.
Take one (1) sumatriptan and naproxen tablet as soon as you notice headache symptoms, or after an attack has already begun.
Do not crush, chew, or break the tablet. Swallow the pill whole.
You may take this medication with or without food.
After taking a tablet: If your headache does not completely go away, or goes away and comes back, you may take a second tablet two (2) hours after the first.
You must wait at least 2 hours before taking a second tablet. Do not take more than 2 sumatriptan and naproxen tablets in 24 hours. If your symptoms have not improved, contact your doctor before taking any more tablets.
Contact your doctor if you have more than five headaches in one month (30 days).
If you take sumatriptan and naproxen every now and then over a long period of time, your doctor may want to check you on a regular basis to make sure the medication is not causing harmful effects. Do not miss any scheduled appointments.
Naproxen can cause you to have unusual results with certain medical tests. Tell any doctor who treats you if you have taken sumatriptan and naproxen within the past 72 hours.
Store this medication at room temperature away from moisture and heat.

What happens if I overdose on Naproxen-sumatriptan?

Seek emergency medical attention if you think you have used too much of this medicine.
Symptoms of a sumatriptan and naproxen overdose are unknown, but may include dizziness, drowsiness, heartburn, stomach pain, nausea, vomiting, breathing problems, black or bloody stools, coughing up blood, and seizure (convulsions).

What happens if I miss a dose of Naproxen-sumatriptan?

Since sumatriptan and naproxen is taken only when needed, it does not have a daily dosing schedule.
Do not take more than 2 sumatriptan and naproxen tablets in 24 hours.
Sourced from everydayhealth.com

Naproxen-sumatriptan