What is Nafcillin?

Nafcillin is an antibiotic in the penicillin group of drugs. It fights bacteria in your body.
Nafcillin is used to treat many different types of infections, especially those caused by staphylococcus bacteria (“staph” infections).
Nafcillin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Nafcillin?

You should not use this medication if you are allergic to nafcillin or to any other penicillin antibiotic, such as amoxicillin (Amoxil), ampicillin (Omnipen, Principen), oxacillin (Bactocill), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.
Before using nafcillin, tell your doctor if you are allergic to cephalosporins such as Ceftin, Cefzil, Keflex, Omnicef, and others, or if you have asthma, liver or kidney disease, or a history of any type of allergy.
Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Nafcillin is usually given for up to 2 days after lab tests show that the infection has cleared.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking nafcillin and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

What should I discuss with my healthcare provider before taking Nafcillin?

You should not use this medication if you are allergic to nafcillin or to any other penicillin antibiotic, such as:

amoxicillin (Amoxil, Amoxicot, Biomox, Dispermox, Trimox)
ampicillin (Omnipen, Principen)
carbenicillin (Geocillin)
cloxacillin (Cloxapen)
dicloxacillin (Dycill, Dynapen)
oxacillin (Bactocill); or
penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids, and others)

Before using nafcillin, tell your doctor if you are allergic to any drugs (especially cephalosporins such as Ceftin, Cefzil, Keflex, Omnicef, and others), or if you have:

asthma
liver disease
kidney disease; or
a history of any type of allergy

If you have any of these conditions, you may need a dosage adjustment or special tests during treatment.
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Nafcillin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Nafcillin Side Effects

What are the possible side effects of Nafcillin?

Get emergency medical help if you have any of these signs of an allergic reaction: hives, itching; fever, stomach pain, muscle or joint pain; difficulty breathing; swelling of your face, lips, tongue, or throat. A delayed allergic reaction to nafcillin can occur as few as 2 days to as many as 4 weeks after you use the medication.
Call your doctor at once if you have any of these serious side effects:

diarrhea that is watery or bloody
fever, chills, body aches, flu symptoms, sores in your mouth and throat
skin rash, bruising, severe tingling, numbness, pain, muscle weakness
blood in your urine, urinating less than usual or not at all; or
pain, swelling, tenderness, or skin changes where the medicine was injected

Less serious side effects are more likely to occur, such as:

nausea, vomiting
vaginal itching or discharge; or
black or “hairy” tongue

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Nafcillin Interactions

What other drugs affect Nafcillin?

Before using nafcillin, tell your doctor if you are using any of the following drugs:

cyclosporine (Gengraf, Neoral, Sandimmune)
a blood thinner such as warfarin (Coumadin); or
an antibiotic such as doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap)

This list is not complete and other drugs may interact with nafcillin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

What should I avoid while taking Nafcillin?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking nafcillin and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Nafcillin Dosage

How should I take Nafcillin?

Nafcillin is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.
Nafcillin is usually given every 4 hours. The medicine must be given slowly through an IV infusion, and can take up to 1 hour to complete.
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.
To be sure this medicine is helping your condition, your blood will need to be tested often. Your liver and kidney function may also need to be tested. Visit your doctor regularly.
Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Nafcillin is usually given for up to 2 days after lab tests show that the infection has cleared.
Nafcillin in vials (bottles) should be stored at room temperature away from moisture and heat.
Nafcillin that is supplied in a premixed frozen solution should be stored in a deep freezer at a temperature of 4 degrees below 0.
Thaw the medicine either in a refrigerator or at room temperature. Do not heat the medicine to thaw it more quickly.
Nafcillin that is thawed in the refrigerator should be used within 21 days. If you have thawed the medicine at room temperature, you must use it within 72 hours. Do not refreeze.
Once nafcillin has been thawed, it should look clear. Do not use the medicine if it looks cloudy or has particles in it, or if the medicine container leaks. Call your doctor or pharmacist for a new prescription

What happens if I overdose on Nafcillin?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include muscle spasms or weakness, muscle pain or twitching, numbness or tingly feeling, confusion, feeling light-headed, fainting, and seizure (black-out or convulsions).

What happens if I miss a dose of Nafcillin?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
Sourced from everydayhealth.com

Nafcillin