Definition
Erythema nodosum is an inflammatory disorder that is characterized by tender, red nodules under the skin.
Overview, Causes, & Risk Factors
In about half of cases, the exact cause of erythema nodosum is unknown. Some cases may be associated with the following:
- Infections. Some of the more common ones are:
- Streptococcus (most common)
- Cat scratch disease
- Chlamydia
- Coccidioidomycosis
- Hepatitis B
- Histoplasmosis
- Leptospirosis
- Mononucleosis (EBV)
- Mycobacteria
- Mycoplasma
- Psittacosis
- Syphilis
- Tuberculosis
- Tularemia
- Yersinia
- Pregnancy
- Sensitivity to certain medications, including:
- Amoxicillin and other penicillins
- Sulfonamides
- Sulfones
- Oral contraceptives
- Other antibiotics
- Progestin
Other associated disorders include leukemia, lymphoma, sarcoidosis, rheumatic fever, Bechet’s disease, and ulcerative colitis.
The condition is more common in women than it is in men.
Pictures & Images
Erythema nodosum associated with sarcoidosis
This picture shows reddish-purple, hard (indurated), painful nodules (Erythema nodosum) that occur most commonly on the shins. These lesions may be anywhere on the body and may be associated with tuberculosis (TB), sarcoidosis, coccidioidomycosis, systemic lupus erythematosis (SLE), fungal infections, or in response to medications.
Erythema nodosum on the foot
This person has erythema nodosum nodules on the feet. The feet are red and painful. This disorder is associated with drugs or infections.
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Erythema nodosum : Overview, Causes, & Risk Factors
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Erythema nodosum : Symptoms & Signs, Diagnosis & Tests
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Erythema nodosum : Treatment
Review Date : 10/12/2009
Reviewed By : Kevin Berman, MD, PhD, Atlanta Center for Dermatologic Disease, Atlanta, GA. Review provided by VeriMed Healthcare. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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